Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.39 |
| ▸ | VEGFA | P15692 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565252 | 0.94 | EGLN1 (0.41) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL6565235 | 0.90 | EGLN1 (0.43) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL6566149 | 0.83 | — | — | |
| Tetrahydrofuran SCHEMBL8630504 | 0.83 | EGLN1 (0.38) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL6567446 | 0.82 | EGLN1 (0.46) | EGLN1EGLN3VEGFAFLT1FTO | |
| SCHEMBL6566297 | 0.80 | KMT2A (0.43) | — | |
| SCHEMBL6567188 | 0.76 | EGLN1 (0.47) | EGLN1EGLN3VEGFAFLT1FTO | |
| SCHEMBL6566140 | 0.73 | MRGPRX4 (0.45) | EGLN1 | |
| SCHEMBL8630490 | 0.73 | EGLN1 (0.43) | EGLN1EGLN3VEGFAFLT1FTO | |
| SCHEMBL8631191 | 0.72 | CNR2 (0.38) | KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |