Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567234 | 0.92 | NR1H3 (0.47) | NR1H3KMT2ASMN1; SMN2PARP10F2 | |
| SCHEMBL6511804 | 0.77 | NR1H3 (0.77) | NR1H3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL5127277 | 0.72 | CA1 (0.52) | MAPTRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL201415 | 0.70 | PARP1 (0.55) | NR1H3KMT2APARP10F2PRSS1 | |
| SCHEMBL203431 | 0.70 | PRSS1 (0.67) | KMT2APARP10F2F10PRSS1 | |
| SCHEMBL203998 | 0.69 | PARP1 (0.58) | NR1H3KMT2APRSS1PARP1 | |
| SCHEMBL13186410 | 0.69 | NR1H4 (0.54) | MAPTRAB9AKMT2AALDH1A1CYP1A2 | |
| SCHEMBL3979585 | 0.68 | PRSS1 (0.65) | KMT2APARP10F2PRSS1PARP1 | |
| SCHEMBL14240960 | 0.68 | KMT2A (0.58) | MAPTRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27572547 | 0.68 | ALDH1A1 (0.61) | MAPTRAB9APRSS1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | disclosed |