Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | C1S | P09871 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566864 | 0.92 | NR1H3 (0.49) | NR1H3PARP10SMN1; SMN2KMT2AF2 | |
| SCHEMBL6513456 | 0.74 | NR1H3 (0.76) | NR1H3SRD5A2KMT2A | |
| SCHEMBL7451063 | 0.72 | NR4A2 (0.70) | PARP10SRD5A2SMN1; SMN2KMT2ANR4A2 | |
| SCHEMBL6566919 | 0.72 | NR1H3 (0.44) | NR1H3SMN1; SMN2F10 | |
| SCHEMBL203431 | 0.72 | PRSS1 (0.67) | PARP10KMT2ANR4A2F2PLG | |
| SCHEMBL3979585 | 0.70 | PRSS1 (0.65) | PARP10KMT2ANR4A2F2PLG | |
| SCHEMBL201415 | 0.70 | PARP1 (0.55) | NR1H3PARP10KMT2AF2PLG | |
| SCHEMBL204344 | 0.69 | NR4A2 (0.56) | PARP10KMT2ANR4A2F2PLG | |
| SCHEMBL7451728 | 0.68 | SIRT2 (0.60) | PARP10KMT2ANR4A2F2PLG | |
| SCHEMBL6511060 | 0.68 | NR1H3 (0.76) | NR1H3KMT2ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | disclosed |