Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568509 | 0.86 | POLB (0.52) | FGFR1SRCPDGFRAEGFRPDGFRB | |
| SCHEMBL4422197 | 0.79 | NAPRT (0.57) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL17169483 | 0.79 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL9285165 | 0.78 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL17849580 | 0.74 | MEN1 (0.60) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4351163 | 0.72 | HTT (0.58) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4350367 | 0.72 | HTT (0.62) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4354002 | 0.72 | MEN1 (0.59) | FGFR1SRCPDGFRAPDGFRBNPC1 | |
| SCHEMBL13756247 | 0.72 | RAB9A (0.81) | PDGFRANPC1RAB9AMEN1KMT2A | |
| SCHEMBL7932199 | 0.72 | MEN1 (0.53) | MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |