Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566872 | 0.79 | CA1 (0.51) | ALDH1A1LMNAHPGDGAAALOX15 | |
| SCHEMBL4351839 | 0.78 | HDAC8 (0.45) | ALDH1A1KDM4EMAPTLMNAHPGD | |
| SCHEMBL4345563 | 0.77 | BRD4 (0.49) | TSHR | |
| SCHEMBL4343612 | 0.76 | ALDH1A1 (0.50) | POLBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4346813 | 0.76 | KMT2A (0.48) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL6567213 | 0.75 | LOXL2 (0.44) | ALDH1A1KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL7793212 | 0.75 | MAPT (0.68) | POLBALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL4357552 | 0.74 | HDAC8 (0.47) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL4349831 | 0.72 | RXFP1 (0.46) | LMNATDP1HPGDKMT2AGAA | |
| SCHEMBL3404445 | 0.72 | ALDH1A1 (0.68) | POLBALDH1A1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |