Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345532 | 0.81 | EGFR (0.34) | EGFRPOLB | |
| SCHEMBL4354194 | 0.80 | KMT2A (0.39) | EGFRPOLB | |
| SCHEMBL4352970 | 0.75 | EGFR (0.38) | EGFRPOLBHDAC8 | |
| SCHEMBL4353715 | 0.75 | EGFR (0.41) | EGFRHDAC1HDAC6 | |
| SCHEMBL4351839 | 0.73 | HDAC8 (0.45) | HDAC1HDAC8HDAC6 | |
| SCHEMBL6568648 | 0.73 | LMNA (0.41) | — | |
| SCHEMBL6566390 | 0.72 | BRD4 (0.48) | POLBKDM4C | |
| SCHEMBL4347039 | 0.72 | APP (0.48) | POLB | |
| SCHEMBL4345563 | 0.70 | BRD4 (0.49) | — | |
| SCHEMBL4358645 | 0.70 | EGFR (0.45) | EGFRKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |