Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347039 | 0.80 | APP (0.48) | LMNAHTTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL4351839 | 0.75 | HDAC8 (0.45) | LMNAHTTHPGDMAPTALDH1A1 | |
| SCHEMBL6566917 | 0.73 | EGFR (0.33) | — | |
| SCHEMBL4345563 | 0.72 | BRD4 (0.49) | CLK4TSHRCYP2C9 | |
| SCHEMBL4346813 | 0.71 | KMT2A (0.48) | HTTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL6566390 | 0.71 | BRD4 (0.48) | LMNAHRH4MAPTALDH1A1TP53 | |
| SCHEMBL6567213 | 0.70 | LOXL2 (0.44) | LMNAHTTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL4358210 | 0.70 | CD38 (0.48) | HTTSMN1; SMN2RAB9AMAPK1HPGD | |
| SCHEMBL6566907 | 0.69 | POLB (0.50) | LMNAHTTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL4347334 | 0.69 | CD38 (0.46) | LMNAMAPK1MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |