Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CNR1 | P21554 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568383 | 0.87 | CNR1 (0.65) | SMN1; SMN2CNR1KMT2AGAAMAPT | |
| SCHEMBL22834260 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL25454925 | 0.79 | EPHX2 (0.77) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL30415729 | 0.76 | LMNA (1.00) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL3761624 | 0.76 | SMN1; SMN2 (0.72) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL8202803 | 0.76 | SMN1; SMN2 (0.85) | SMN1; SMN2CNR1LMNAEPHX2MAPT | |
| SCHEMBL11926730 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL30416642 | 0.76 | SMN1; SMN2 (0.75) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 | |
| SCHEMBL3897267 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2CNR1LMNAKMT2AALDH1A1 | |
| SCHEMBL14574176 | 0.75 | EPHX2 (0.64) | SMN1; SMN2CNR1LMNAKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |