Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567211 | 0.83 | RAB9A (0.42) | NR1H3NPC1RAB9AMAPTMAOB | |
| SCHEMBL6512034 | 0.78 | NR1H3 (0.71) | NR1H3NPC1RAB9AMAPTALOX15 | |
| SCHEMBL6567234 | 0.72 | NR1H3 (0.47) | NR1H3SMN1; SMN2F10 | |
| SCHEMBL6566864 | 0.70 | NR1H3 (0.49) | NR1H3RAB9AMAPTMAOBSMN1; SMN2 | |
| SCHEMBL1387303 | 0.69 | OPRM1 (0.59) | NPC1RAB9AMAPTALOX15MAOA | |
| SCHEMBL30417964 | 0.69 | OPRM1 (0.59) | NPC1RAB9AMAPTALOX15MAOA | |
| SCHEMBL203431 | 0.67 | PRSS1 (0.67) | OPRM1OPRD1F10 | |
| SCHEMBL3979585 | 0.66 | PRSS1 (0.65) | — | |
| SCHEMBL10990677 | 0.66 | KDM4E (0.53) | MAOBSMN1; SMN2F10ALDH1A1 | |
| SCHEMBL30343815 | 0.66 | F10 (0.57) | NPC1RAB9AMAOBSMN1; SMN2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | disclosed |