Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650074 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL10361254 | 0.80 | EPHX2 (0.65) | MEN1KMT2AKDM4EALDH1A1RAB9A | |
| SCHEMBL6568610 | 0.79 | RAB9A (0.63) | MEN1KMT2AKDM4EALDH1A1RAB9A | |
| SCHEMBL4347065 | 0.78 | RAB9A (0.66) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL6568591 | 0.78 | TAS1R3 (0.61) | MEN1KMT2AALDH1A1NPC1EPHX2 | |
| SCHEMBL6567565 | 0.75 | CNR1 (0.71) | DHODHEPHX2SMN1; SMN2LMNA | |
| SCHEMBL4342381 | 0.75 | KMT2A (0.68) | MEN1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL6567241 | 0.74 | EPHX1 (0.59) | MEN1KMT2AKDM4EALDH1A1RAB9A | |
| SCHEMBL21568131 | 0.71 | KMT2A (0.58) | MEN1KMT2AKDM4EALDH1A1RAB9A | |
| SCHEMBL22803295 | 0.70 | EPHX1 (0.57) | MEN1KMT2AKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |