Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346187 | 0.85 | EPHX1 (0.63) | KMT2ARAB9ANPC1EPHX1SMN1; SMN2 | |
| SCHEMBL21862006 | 0.85 | KMT2A (0.62) | KMT2AGAARAB9ANPC1EPHX1 | |
| SCHEMBL2752019 | 0.85 | HTT (0.69) | KMT2ARAB9ANPC1EPHX1SMN1; SMN2 | |
| SCHEMBL2752905 | 0.82 | RAB9A (0.61) | KMT2ARAB9ANPC1EPHX1SMN1; SMN2 | |
| SCHEMBL2835880 | 0.79 | EPHX1 (0.66) | KMT2ARAB9ANPC1EPHX1SMN1; SMN2 | |
| SCHEMBL2752803 | 0.78 | KMT2A (0.73) | KMT2AGAARAB9ANPC1MEN1 | |
| SCHEMBL813709 | 0.77 | EPHX1 (1.00) | KMT2AGAARAB9ANPC1EPHX1 | |
| SCHEMBL15975491 | 0.75 | RAB9A (1.00) | KMT2AGAARAB9ANPC1EPHX1 | |
| SCHEMBL2750450 | 0.75 | EPHX1 (0.97) | KMT2AGAARAB9ANPC1EPHX1 | |
| SCHEMBL4598339 | 0.75 | KMT2A (0.85) | KMT2AGAARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |