Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567274 | 0.78 | CA2 (0.48) | POLBKMT2AALDH1A1MEN1CA1 | |
| SCHEMBL8516114 | 0.69 | GAA (0.58) | KMT2AALDH1A1MEN1CYP1A2LMNA | |
| SCHEMBL5319979 | 0.67 | ALDH1A1 (0.65) | POLBKMT2AALDH1A1MEN1CA1 | |
| SCHEMBL12312513 | 0.66 | TTR (0.45) | POLBTHRATHRBALDH1A1CA1 | |
| SCHEMBL2926157 | 0.65 | HSP90AB1 (0.63) | POLBKMT2AALDH1A1MEN1CA2 | |
| SCHEMBL10659008 | 0.65 | KMT2A (0.48) | KMT2AMEN1 | |
| SCHEMBL14948951 | 0.64 | TSHR (0.41) | POLBKMT2ATHRBALDH1A1LMNA | |
| SCHEMBL8199324 | 0.64 | AKR1C2 (0.49) | POLBKMT2ATHRBALDH1A1MEN1 | |
| SCHEMBL9888804 | 0.64 | ALDH1A1 (0.42) | KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL3723839 | 0.64 | BLM (0.47) | POLBKMT2AALDH1A1MEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |