Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347034 | 0.84 | EPHX2 (0.67) | EPHX2MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL27929186 | 0.83 | CNR1 (0.53) | EPHX2MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL8602435 | 0.83 | EPHX2 (0.69) | EPHX2MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL8602439 | 0.83 | EPHX2 (0.69) | EPHX2MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL6568451 | 0.80 | KDM4E (0.69) | EPHX2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL30223252 | 0.79 | MEN1 (0.72) | EPHX2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6568480 | 0.79 | ALDH1A1 (0.50) | EPHX2MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6226728 | 0.79 | EPHX2 (0.56) | EPHX2MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL6567241 | 0.78 | EPHX1 (0.59) | EPHX2POLBMEN1KMT2ARAB9A | |
| SCHEMBL27929217 | 0.77 | CNR1 (0.66) | RAB9ANPC1SMN1; SMN2KDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |