SCHEMBL6567915

SCHEMBL6567915

[CH](CCc1cccnc1)CCC1CCCCC1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
PKM P14618 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
HRH3 Q9Y5N1 1/20 0.43
CHRNA7 P36544 2/20 0.42
NCOA1 Q15788 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41
CYP11B2 P19099 1/20 0.41
CYP2A6 P11509 1/20 0.41
FDPS P14324 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6569542 0.82 CYP2A6 (0.53) LMNAKDM4EALDH1A1PKMSLC6A2
SCHEMBL7407607 0.82 CYP2A6 (0.53) LMNAKDM4EALDH1A1PKMSLC6A2
SCHEMBL6570980 0.82 SIGMAR1 (0.45)
SCHEMBL7427487 0.80 CYP2A6 (0.54) LMNAKDM4EALDH1A1PKMSLC6A2
SCHEMBL7407399 0.78 KDM4E (0.48) KDM4EALDH1A1PKMSLC6A2SLC6A4
SCHEMBL8200213 0.76 SLC6A2 (0.58) LMNAKDM4EALDH1A1PKMSLC6A2
SCHEMBL8911540 0.75 KDM4E (0.54) KDM4EALDH1A1PKMCHRNA7CYP11B2
Bicarbonate SCHEMBL9521052 0.74 TBXAS1 (0.58) LMNANCOA1NCOA3TDP1L3MBTL1
SCHEMBL17064309 0.73 CYP2A6 (0.58) SLC6A2SLC6A4HRH3CHRNA7CYP2A6
SCHEMBL27686945 0.73 KDM4E (0.56) KDM4EALDH1A1PKMCHRNA7CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404325-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2004-04-07 EP disclosed
WO-2002096420-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2002-12-05 WO disclosed
EP-1105112-A2 COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-13 EP disclosed
US-6140357-A STIMULATING GROWTH OF DAMAGED PERIPHERAL NERVES BY ADMINISTERING TO DAMAGED PERIPHERAL NERVES NEUROTROPHIC N-GLYOXYLPROLYL ESTER COMPOUNDHAVING AN AFFINITY FOR IMMUNOPHILINS GPI NIL HOLDINGS, INC. (US) 2000-10-31 US disclosed
EP-1011650-A1 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS Amgen Inc., (US) 2000-06-28 EP disclosed
EP-0983054-A1 HAIR GROWTH COMPOSITIONS AND USES GPI NIL Holdings, Inc. (US) 2000-03-08 EP disclosed
WO-2000009108-A2 COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO disclosed
WO-1999014998-A2 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS AMGEN INC. (US) 1999-04-01 WO disclosed
US-5859031-A Small molecule inhibitors of rotamase enzyme activity GPI NIL HOLDINGS, INC. (US) 1999-01-12 US disclosed
WO-1998055090-A1 HAIR GROWTH COMPOSITIONS AND USES GUILFORD PHARMACEUTICALS INC. (US) 1998-12-10 WO disclosed
US-5795908-A FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS GPI NIL HOLDINGS, INC. (US) 1998-08-18 US disclosed