Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | PNLIP | P16233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567839 | 0.82 | BCL9 (0.40) | HRH1CCR3TOP2AALDH1A1KDM4E | |
| SCHEMBL6568478 | 0.75 | HRH1 (0.48) | HRH1CCR3HSP90AB1TOP2A | |
| SCHEMBL6569446 | 0.75 | CCR3 (0.56) | HRH1CCR3HSP90AB1TOP2A | |
| SCHEMBL5414704 | 0.73 | HRH1 (0.58) | HRH1CCR3ALDH1A1KDM4EKCNMA1 | |
| SCHEMBL6570421 | 0.72 | HRH1 (0.51) | HRH1CCR3HTR2CHTR2BIRAK1 | |
| SCHEMBL5691641 | 0.72 | HRH1 (0.40) | HRH1CCR3PNLIPALDH1A1KDM4E | |
| SCHEMBL2924499 | 0.69 | HTR2C (0.56) | HTR2CHTR2B | |
| SCHEMBL6569252 | 0.68 | HRH1 (0.54) | HRH1CCR3 | |
| Hydrochloric Acid SCHEMBL4995893 | 0.68 | HTR2C (0.55) | HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8477391 | 0.65 | HSP90AB1 (0.62) | CCR8HSP90AB1TOP2ABRPF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |