Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 7/20 | 0.56 |
| ▸ | HRH1 | P35367 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 7/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568478 | 0.94 | HRH1 (0.48) | CCR3HRH1KCNH2TOP2AHSP90AB1 | |
| SCHEMBL6570814 | 0.84 | HRH1 (0.39) | CCR3HRH1KCNH2TOP2AHSP90AB1 | |
| SCHEMBL6568905 | 0.76 | HRH1 (0.46) | CCR3HRH1KCNH2UTS2R | |
| SCHEMBL6567839 | 0.76 | BCL9 (0.40) | CCR3HRH1TOP2AUTS2R | |
| SCHEMBL6568359 | 0.75 | CCR8 (0.41) | CCR3HRH1TOP2AHSP90AB1 | |
| SCHEMBL4908937 | 0.73 | CCR3 (0.46) | CCR3HRH1KCNH2TOP2AHSP90AB1 | |
| SCHEMBL5403357 | 0.71 | CCR3 (1.00) | CCR3HRH1KCNH2 | |
| SCHEMBL1928032 | 0.71 | HRH1 (0.44) | CCR3HRH1KCNH2TOP2AHSP90AB1 | |
| SCHEMBL6569255 | 0.70 | HRH1 (0.39) | CCR3HRH1KCNH2TOP2AHSP90AB1 | |
| SCHEMBL6569095 | 0.70 | HRH1 (0.42) | CCR3HRH1KCNH2TOP2AHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |