Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.54 |
| ▸ | CCR3 | P51677 | 20/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568905 | 0.80 | HRH1 (0.46) | HRH1CCR3KCNH2 | |
| SCHEMBL6570586 | 0.78 | CCR3 (0.39) | HRH1CCR3KCNH2 | |
| SCHEMBL5408959 | 0.76 | HRH1 (0.72) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL6570664 | 0.72 | SLC6A2 (0.48) | HRH1CCR3KCNH2 | |
| SCHEMBL18841174 | 0.71 | CCR3 (0.74) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL2923421 | 0.70 | HRH1 (1.00) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL2918679 | 0.70 | HRH1 (1.00) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL6568478 | 0.70 | HRH1 (0.48) | HRH1CCR3KCNH2 | |
| SCHEMBL6569446 | 0.69 | CCR3 (0.56) | HRH1CCR3KCNH2 | |
| SCHEMBL13324592 | 0.69 | HRH1 (0.70) | HRH1CCR3KCNH2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |