Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 13/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 13/20 | 0.57 |
| ▸ | PDK3 | Q15120 | 13/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 13/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.57 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27556795 | 1.00 | PTGES2 (0.60) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6571287 | 0.91 | NR1H2 (0.64) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL27529485 | 0.87 | ABCC9 (0.58) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6571237 | 0.87 | ABCC9 (0.58) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL27553234 | 0.87 | PTGES2 (0.65) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6570941 | 0.87 | PTGES2 (0.65) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6357232 | 0.84 | NR1H2 (0.65) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608432 | 0.83 | PDK1 (0.69) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608430 | 0.83 | PDK1 (0.69) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737307 | 0.82 | PDK1 (0.65) | PTGES2PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |
| CN-1303281-A | Application of compound in enhancing activity of pyruvate dehydrogenase | ASTRA ZENECA LTD (SE) | 2001-07-11 | — | — | CN | disclosed |