Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733496 | 0.87 | KDM4E (0.47) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL3381072 | 0.82 | GAA (0.77) | POLBSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL16433948 | 0.81 | POLB (0.62) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL4151517 | 0.80 | SMN1; SMN2 (0.72) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL16433947 | 0.78 | POLB (0.59) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL13216178 | 0.78 | POLB (0.59) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL10008027 | 0.78 | ALDH1A1 (0.59) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL13236576 | 0.78 | POLB (0.59) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL28242435 | 0.78 | ALDH1A1 (0.67) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL24023500 | 0.77 | POLB (1.00) | POLBSMN1; SMN2ALDH1A1KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |