Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566870 | 0.88 | HPGD (0.56) | MEN1KMT2APOLBL3MBTL1MAPT | |
| SCHEMBL4345924 | 0.82 | ALDH1A1 (0.52) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL8415139 | 0.81 | MEN1 (0.62) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL8944807 | 0.80 | GAA (0.53) | KMT2APOLBL3MBTL1LMNAMAPT | |
| SCHEMBL3106393 | 0.80 | KDM4E (0.57) | MEN1KMT2APOLBL3MBTL1LMNA | |
| SCHEMBL16150319 | 0.77 | CYP3A4 (0.66) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL11740673 | 0.77 | ESR1 (0.49) | MEN1KMT2APOLBL3MBTL1LMNA | |
| SCHEMBL5592685 | 0.75 | MAPT (0.63) | MEN1KMT2APOLBL3MBTL1LMNA | |
| SCHEMBL27486195 | 0.75 | CYP4F2 (0.54) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL5675525 | 0.74 | MEN1 (0.52) | MEN1KMT2APOLBL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |