SCHEMBL8944807

SCHEMBL8944807

CCOC(=O)CCC(=O)Nc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 6/20 0.53
ALDH1A1 P00352 3/20 0.53
TDP1 Q9NUW8 2/20 0.53
LMNA P02545 2/20 0.49
MAPT P10636 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 1/20 0.46
HTT P42858 3/20 0.45
PKM P14618 1/20 0.45
VCAM1 P19320 1/20 0.43
POLB P06746 1/20 0.42
EGFR P00533 1/20 0.41
ERBB3 P21860 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944534 0.88 L3MBTL1 (0.60) GAAALDH1A1TDP1MAPTL3MBTL1
SCHEMBL29282569 0.82 ALDH1A1 (0.62) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL9812401 0.81 GAA (0.60) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL6568635 0.80 MEN1 (0.55) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL31152144 0.80 GAA (0.57) GAAALDH1A1LMNAMAPTKMT2A
SCHEMBL11798744 0.80 ALDH1A1 (0.58) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL83910 0.80 GAA (0.57) GAAALDH1A1LMNAMAPTKMT2A
SCHEMBL9575165 0.80 GAA (0.70) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL1410855 0.79 GAA (0.62) GAAALDH1A1TDP1LMNAMAPT
SCHEMBL3483031 0.79 GAA (0.66) GAAALDH1A1TDP1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578731-A ASYMMETRICAL HYDRAZINE DERIVATIVE CIBA-GEIGY CORPORATION (US) 1996-11-26 US disclosed
US-5554754-A PHOTOSTABILIZERS CIBA-GEIGY CORPORATION (US) 1996-09-10 US disclosed
US-5470980-A Light stabilizers for polymers that can be grafted to polymers CIBA-GEIGY CORPORATION (US) 1995-11-28 US disclosed
EP-0647626-A1 Azadicarboxylic acid derivatives containing hindered amine moieties as polymer stabilisers CIBA-GEIGY AG (CH) 1995-04-12 EP disclosed
US-5352719-A Blended with synthetic or natural polymers ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-10-04 US disclosed
US-5319090-A Benzotriazole and oxanilide UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-06-07 US disclosed
US-5233047-A Benzotriazole UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-08-03 US disclosed
EP-0303280-B1 PHENOLIC ANTIOXIDANT HYDRAZIDES ATOCHEM NORTH AMERICA, INC. (US) 1993-03-24 EP disclosed
US-5116976-A HINDERED AMINE LIGHT STABILIZER HYDRAZIDES ATOCHEM NORTH AMERICA, INC (US) 1992-05-26 US disclosed
EP-0467344-A1 Hindered amine light stabilizer hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-01-22 EP disclosed
US-5041545-A 2-hydroxybenzophenone hydrazides and derivatives thereof ATOCHEM NORTH AMERICA, INC. (US) 1991-08-20 US disclosed
US-4980420-A Benzotriazole and oxanilide UV absorber hydrazides ATOCHEM NORTH AMERICA, INC. (US) 1990-12-25 US disclosed
EP-0303280-A2 Phenolic antioxidant hydrazides ATOCHEM NORTH AMERICA, INC. (US) 1989-02-15 EP disclosed
US-4801749-A Phenolic antioxidant hydrazides PENNWALT CORPORATION (US) 1989-01-31 US disclosed