Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLB1 | P16278 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084136 | 1.00 | ALDH1A1 (0.44) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL7375648 | 0.86 | HRH3 (0.41) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL21276612 | 0.79 | GLB1 (0.54) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL19275199 | 0.79 | GLB1 (0.54) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL2115306 | 0.78 | SIGMAR1 (0.41) | ALDH1A1POLBHTR7HRH3KDM4E | |
| SCHEMBL14685579 | 0.78 | SIGMAR1 (0.41) | ALDH1A1POLBHTR7HRH3KDM4E | |
| SCHEMBL20109895 | 0.77 | GBA1 (0.39) | GBA1GLB1 | |
| SCHEMBL13182863 | 0.77 | EBP (0.59) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL4089010 | 0.77 | HRH3 (0.43) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 | |
| SCHEMBL18762872 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1POLBTHRBSMN1; SMN2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428820-A1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2004-06-16 | — | — | EP | disclosed |
| EP-1100503-A2 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | SOCIETE CIVILE BIOPROJET (FR) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006254-A2 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | SOCIETE CIVILE BIOPROJET (FR) | 2000-02-10 | — | — | WO | disclosed |