SCHEMBL6569149

SCHEMBL6569149

CC(C)OC(=O)c1cccc(I)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.56
RAB9A P51151 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
HTT P42858 2/20 0.56
MAPT P10636 2/20 0.56
CA12 O43570 6/20 0.54
CA1 P00915 6/20 0.54
CA2 P00918 6/20 0.54
CA7 P43166 6/20 0.54
CA9 Q16790 6/20 0.54
CA14 Q9ULX7 6/20 0.54
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
PDCD1 Q15116 1/20 0.50
CD274 Q9NZQ7 1/20 0.50
ALDH1A1 P00352 3/20 0.49
LMNA P02545 1/20 0.47
JMJD6 Q6NYC1 1/20 0.44
TRPA1 O75762 1/20 0.44
CYP4F2 P78329 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL43683 0.87 NPC1 (0.65) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL17967311 0.83 SLC6A2 (0.46) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL14335273 0.81 MAPT (0.41) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL10181240 0.81 CA12 (0.62) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL27683331 0.80 RAB9A (0.62) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL6233392 0.80 NPC1 (0.62) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL30678268 0.80 NPC1 (0.62) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL161684 0.80 CA12 (0.67) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL161683 0.80 NPC1 (0.58) NPC1RAB9ASMN1; SMN2HTTMAPT
SCHEMBL6057062 0.80 RAB9A (0.58) NPC1RAB9ASMN1; SMN2HTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140072-B1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-04-14 EP disclosed
EP-1140072-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2003-04-16 EP disclosed
EP-1140072-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2001-10-10 EP disclosed
WO-2000040239-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-07-13 WO disclosed