Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 12/20 | 0.36 |
| ▸ | CCR3 | P51677 | 12/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567411 | 0.79 | HRH1 (0.46) | P2RX7FPR2PROKR1HRH1CCR3 | |
| SCHEMBL6569359 | 0.77 | HRH1 (0.38) | P2RX7HRH1CCR3KCNH2 | |
| SCHEMBL6569229 | 0.76 | HRH1 (0.47) | P2RX7HRH1CCR3KCNH2 | |
| SCHEMBL5416896 | 0.76 | HRH1 (0.65) | HRH1CCR3KCNH2 | |
| SCHEMBL5689537 | 0.76 | HRH1 (0.51) | HRH1CCR3KCNH2 | |
| SCHEMBL5420195 | 0.76 | HRH1 (0.51) | HRH1CCR3KCNH2 | |
| SCHEMBL6569275 | 0.71 | HRH1 (0.46) | HRH1CCR3KCNH2KMT2AMEN1 | |
| SCHEMBL6570411 | 0.70 | HRH1 (0.45) | P2RX7HRH1CCR3KCNH2 | |
| SCHEMBL6570601 | 0.70 | HRH1 (0.43) | HRH1CCR3KCNH2 | |
| SCHEMBL7016612 | 0.69 | HRH1 (0.41) | P2RX7FPR2PROKR1HRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |