Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.47 |
| ▸ | CCR3 | P51677 | 15/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.38 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569359 | 0.83 | HRH1 (0.38) | HRH1CCR3KCNH2LGALS8LGALS3 | |
| SCHEMBL6570411 | 0.83 | HRH1 (0.45) | HRH1CCR3KCNH2LGALS8LGALS3 | |
| SCHEMBL6567411 | 0.83 | HRH1 (0.46) | HRH1CCR3KCNH2P2RX7 | |
| SCHEMBL6570601 | 0.78 | HRH1 (0.43) | HRH1CCR3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL6569255 | 0.77 | HRH1 (0.39) | HRH1CCR3KCNH2LGALS8LGALS3 | |
| SCHEMBL6569095 | 0.77 | HRH1 (0.42) | HRH1CCR3KCNH2UTS2R | |
| SCHEMBL6569264 | 0.76 | CA1 (0.37) | HRH1CCR3KCNH2P2RX7 | |
| SCHEMBL6569275 | 0.75 | HRH1 (0.46) | HRH1CCR3KCNH2LGALS8LGALS3 | |
| SCHEMBL7016612 | 0.74 | HRH1 (0.41) | HRH1CCR3KCNH2P2RX7UTS2R | |
| SCHEMBL6681927 | 0.73 | SLC6A4 (0.43) | HRH1CCR3KCNH2P2RX7UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |