Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.42 |
| ▸ | CCR3 | P51677 | 11/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.37 |
| ▸ | TOP2A | P11388 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569255 | 0.94 | HRH1 (0.39) | HRH1CCR3HSP90AB1TOP2AKCNH2 | |
| SCHEMBL6567411 | 0.77 | HRH1 (0.46) | HRH1CCR3KCNH2 | |
| SCHEMBL6569229 | 0.77 | HRH1 (0.47) | HRH1CCR3KCNH2UTS2R | |
| SCHEMBL6570421 | 0.76 | HRH1 (0.51) | HRH1CCR3KCNH2HTR2C | |
| SCHEMBL6568478 | 0.76 | HRH1 (0.48) | HRH1CCR3HSP90AB1TOP2AKCNH2 | |
| SCHEMBL6570411 | 0.76 | HRH1 (0.45) | HRH1CCR3KCNH2HTR6HTR2C | |
| SCHEMBL6569389 | 0.73 | HRH1 (0.46) | HRH1CCR3KCNH2UTS2R | |
| SCHEMBL5406407 | 0.73 | HRH1 (0.74) | HRH1CCR3KCNH2 | |
| SCHEMBL6569275 | 0.71 | HRH1 (0.46) | HRH1CCR3KCNH2HTR2C | |
| SCHEMBL6570601 | 0.70 | HRH1 (0.43) | HRH1CCR3KCNH2MCL1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |