Sugi Predict

Sugi Predict / Compounds / SCHEMBL656946

SCHEMBL656946

SCHEMBL656946

O=C(O)CC(CC(=O)O)c1cccc2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.62
▸ CYP2C9 P11712 2/20 0.62
▸ CYP2C19 P33261 2/20 0.62
▸ HTT P42858 1/20 0.62
▸ TDP1 Q9NUW8 2/20 0.50
▸ ALDH1A1 P00352 4/20 0.47
▸ ACP3 P15309 3/20 0.47
▸ CYP1A2 P05177 2/20 0.47
▸ KDM4E B2RXH2 2/20 0.46
▸ GABBR2 O75899 1/20 0.46
▸ GABBR1 Q9UBS5 1/20 0.46
▸ NR4A1 P22736 1/20 0.46
▸ NR4A2 P43354 1/20 0.46
▸ NR4A3 Q92570 1/20 0.46
▸ CASP1 P29466 1/20 0.43
▸ CTNNB1 P35222 1/20 0.42
▸ GLA P06280 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ PTGER4 P35408 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14582250 0.92 HTT (0.55) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL657068 0.91 HPGD (0.54) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL3814689 0.90 CYP2C9 (0.56) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL11040097 0.90 GABBR2 (0.57) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL5280903 0.88 CYP2C19 (0.51) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL5280121 0.88 CYP2C19 (0.51) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL9807303 0.87 HPGD (0.54) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL10354936 0.84 HPGD (0.60) HPGDCYP2C9CYP2C19HTTTDP1
SCHEMBL9185451 0.83 CYP2C9 (0.50) HPGDCYP2C9CYP2C19HTTKDM4E
SCHEMBL8391655 0.82 CYSLTR2 (0.49) HPGDCYP2C9CYP2C19HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0918754-B1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTAPHARM SPA (IT) 2007-12-05 — — EP claimed
US-6075033-A Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents ROTTA RESEARCH LABORATORIUM S.P.A (IT) 2000-06-13 — — US claimed
EP-0918754-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-06-02 — — EP claimed
WO-1998000404-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-01-08 — — WO claimed
CN-117247317-A Based on CO 2 Method for synthesizing dicarboxylic acid/tricarboxylic acid compound 四川大学 2023-12-19 — — CN disclosed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 — — EP disclosed
US-8912186-B2 Allosteric protein kinase modulators UNIVERSITAET DES SAARLANDES (DE) 2014-12-16 — — US disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 — — US disclosed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 — — EP disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 — — WO disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 — — EP disclosed
EP-0918754-B1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTAPHARM SPA (IT) 2007-12-05 — — EP disclosed
EP-0839137-B1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LAB (IT) 2001-08-16 — — EP disclosed
US-6075033-A Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents ROTTA RESEARCH LABORATORIUM S.P.A (IT) 2000-06-13 — — US disclosed
US-5922875-A ANTIULCER AGENTS, ANTITUMOR AGENTS TREATING GASTROINTESTINAL DISORDER, CENTRAL NERVOUS SYSTEM DISORDER LINKED TO IMBALANCES IN THE NEURAL PHYSIOLOGICAL LEVELS OF GASTRIN OR OTHER BIOACTIVE POLYPEPTIDES, EYE INFLAMMATION CAUSED BY SURGERY ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-07-13 — — US disclosed
EP-0918754-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-06-02 — — EP disclosed
EP-0839137-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-05-06 — — EP disclosed
WO-1998000404-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-01-08 — — WO disclosed
WO-1997002248-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1997-01-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB HPGD 4359/4885CYP2C9 4696/4885CYP2C19 4532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.