Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.54 |
| ▸ | HRH1 | P35367 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570161 | 0.83 | MAOB (0.48) | HRH3SIGMAR1MAOB | |
| SCHEMBL22561783 | 0.76 | HRH3 (0.74) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL7982901 | 0.75 | HRH3 (0.73) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL27689434 | 0.73 | HRH3 (0.71) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| Hydrochloric Acid SCHEMBL7369873 | 0.73 | HRH3 (0.73) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL14970774 | 0.71 | ALDH1A1 (0.84) | HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL1276590 | 0.70 | ALDH1A1 (1.00) | HRH3KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL11227514 | 0.70 | ALDH1A1 (1.00) | HRH3KDM4EALDH1A1SIGMAR1 | |
| Pitolisant SCHEMBL117648 | 0.70 | HRH3 (1.00) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL5487605 | 0.70 | HRH3 (0.61) | HRH3HRH1SLC6A2CHRM2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |