Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.78 |
| ▸ | NPC1 | O15118 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.78 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.78 |
| ▸ | RELA | Q04206 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167648 | 0.85 | RAB9A (0.72) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL31612285 | 0.82 | RAB9A (0.68) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL3635519 | 0.82 | RAB9A (0.67) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL13210626 | 0.80 | RAB9A (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL18719840 | 0.80 | RAB9A (0.74) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL15695713 | 0.79 | ALDH1A1 (0.67) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL2665808 | 0.78 | RAB9A (0.62) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL7783342 | 0.78 | EPHX1 (0.73) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL10144689 | 0.78 | RAB9A (0.73) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL24363257 | 0.77 | RAB9A (0.61) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214862-A1 | Aromatic dicarboxylic acid derivatives | LESER-REIFF ULRIKE | 2004-10-28 | — | — | US | claimed |
| US-20030013757-A1 | Aromatic dicarboxylic acid derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-16 | — | — | US | claimed |
| US-20040214862-A1 | Aromatic dicarboxylic acid derivatives | LESER-REIFF ULRIKE | 2004-10-28 | — | — | US | disclosed |
| US-6784173-B2 | ANTIPROLIFERATIVE AGENTS; ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2004-08-31 | — | — | US | disclosed |
| EP-1401824-A2 | AROMATIC HYDROXAMIC ACID DERIVATIVES USEFUL AS HDAC INHIBITORS | F. Hoffman-la Roche AG (CH) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003011851-A2 | AROMATIC HYDROXAMIC ACID DERIVATIVES USEFUL AS HDAC INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2003-02-13 | — | — | WO | disclosed |
| US-20030013757-A1 | Aromatic dicarboxylic acid derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214862-A1 | Aromatic dicarboxylic acid derivatives | HDAC1, HDAC2, HDAC11 | RAB9A 3059/4885NPC1 2721/4885ALDH1A1 71/4885 |
| US-20030013757-A1 | Aromatic dicarboxylic acid derivatives | HDAC1, HDAC2, HDAC11 | RAB9A 3059/4885NPC1 2721/4885ALDH1A1 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.