Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Timcodar SCHEMBL3673444 | 1.00 | L3MBTL1 (0.37) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| SCHEMBL6570448 | 1.00 | L3MBTL1 (0.37) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| Timcodar SCHEMBL1492143 | 1.00 | L3MBTL1 (0.37) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| Timcodar SCHEMBL30929684 | 0.96 | ALDH1A1 (0.36) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| SCHEMBL6573929 | 0.95 | L3MBTL1 (0.40) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| SCHEMBL6573934 | 0.95 | L3MBTL1 (0.40) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| SCHEMBL6572477 | 0.93 | SLC2A1 (0.39) | L3MBTL1KMT2ALMNASMN1; SMN2SLC2A1 | |
| SCHEMBL6570405 | 0.93 | SLC2A1 (0.39) | L3MBTL1KMT2ALMNASMN1; SMN2SLC2A1 | |
| SCHEMBL6572534 | 0.92 | SLC2A4 (0.39) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 | |
| SCHEMBL6570385 | 0.92 | SLC2A4 (0.39) | L3MBTL1MAPK1ALDH1A1KMT2ALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797567-B1 | NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY | VERTEX PHARMA (US) | 2004-02-11 | — | — | EP | claimed |
| US-5840736-A | PEPTIDES FOR NERVE GROWTH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-11-24 | — | — | US | claimed |
| EP-1420009-A2 | Novel amino acid derivatives with improved multi-drug resistance activity | Vertex Pharmaceuticals Incorporated (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-0797567-B1 | NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY | VERTEX PHARMA (US) | 2004-02-11 | — | — | EP | disclosed |
| EP-0946190-B1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE OUTGROWTH | VERTEX PHARMA (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6284778-B1 | NEUROTROPHIC AGENT | VERTEX PHARMACEUTICALS INCORPORATED | 2001-09-04 | — | — | US | disclosed |
| US-5543423-A | USED IN MULTI-DRUG RESISTANCE CANCER THERAPY | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-08-06 | — | — | US | disclosed |