SCHEMBL6570549

SCHEMBL6570549

[CH2]C(Cc1ccccc1)c1nccs1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.43
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
CTSA P10619 3/20 0.40
PKM P14618 1/20 0.39
HSPA1A P0DMV8 1/20 0.38
HSPA5 P11021 1/20 0.38
HSPA9 P38646 1/20 0.38
HSPA2 P54652 1/20 0.38
PTPRB P23467 1/20 0.37
ADRB3 P13945 1/20 0.37
PLA2G4A P47712 1/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
CES1 P23141 1/20 0.36
CYP19A1 P11511 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7610883 0.81 ADRB3 (0.45) PDPK1CTSAPKMHSPA1AHSPA5
SCHEMBL4375068 0.81 ADRB3 (0.45) PDPK1CTSAPKMHSPA1AHSPA5
SCHEMBL14962698 0.79 MAOA (0.44) PDPK1SLC6A2SLC6A4SLC6A3CTSA
SCHEMBL6685124 0.79 EPHX1 (0.44) PDPK1SLC6A2SLC6A4SLC6A3CTSA
SCHEMBL14968411 0.79 MAOA (0.44) PDPK1SLC6A2SLC6A4SLC6A3CTSA
SCHEMBL6685119 0.79 PDPK1 (0.43) PDPK1SLC6A2SLC6A4SLC6A3CTSA
SCHEMBL8143963 0.79 EPHX1 (0.44) PDPK1SLC6A2SLC6A4SLC6A3CTSA
SCHEMBL4379883 0.79 EPHX1 (0.44) PDPK1SLC6A2SLC6A4SLC6A3CTSA
Hydrochloric Acid SCHEMBL22691671 0.78 EPHX1 (0.42) PDPK1SLC6A2SLC6A4SLC6A3CTSA
Hydrochloric Acid SCHEMBL22691669 0.78 EPHX1 (0.42) PDPK1SLC6A2SLC6A4SLC6A3CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1178912-C Small molecule inhibitors of rotamase enzyme activity ������˹ҩƷ��˾ 2004-12-08 CN disclosed
CN-1542001-A Small molecule inhibitors of rotamase enzyme activity GPI����عɹ�˾ 2004-11-03 CN disclosed
EP-1404325-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2004-04-07 EP disclosed
WO-2002096420-A2 METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY GUILFORD PHARMACEUTICALS INC. (US) 2002-12-05 WO disclosed
CN-1336930-A Bridged heterocyclic derivatives GPINIL HOLDING CORP (US) 2002-02-20 CN disclosed
EP-1127049-A1 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL Holdings, Inc. (US) 2001-08-29 EP disclosed
EP-1011650-A1 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS Amgen Inc., (US) 2000-06-28 EP disclosed
WO-2000016603-A2 BRIDGED HETEROCYCLIC DERIVATIVES GPI NIL HOLDINGS, INC. (US) 2000-03-30 WO disclosed
WO-1999014998-A2 METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS AMGEN INC. (US) 1999-04-01 WO disclosed
CN-1187188-A Small molecule inhibitors of rotamase enzyme activity GUILFORD PHARM INC (US) 1998-07-08 CN disclosed