Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571185 | 0.97 | LMNA (0.71) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL6573530 | 0.93 | CYP2C19 (0.74) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL6572262 | 0.86 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL6573527 | 0.83 | SMN1; SMN2 (0.65) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL2969374 | 0.83 | SMN1; SMN2 (0.74) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL9246238 | 0.80 | LMNA (0.72) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL11474969 | 0.79 | CYP2C19 (1.00) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL6569993 | 0.79 | LMNA (0.68) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11489984 | 0.78 | CYP2C19 (0.98) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL28677732 | 0.78 | SMN1; SMN2 (0.63) | LMNASMN1; SMN2CYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |
| EP-1109550-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013683-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |