Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572262 | 0.97 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL6569993 | 0.93 | LMNA (0.68) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL6571185 | 0.86 | LMNA (0.71) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL6570770 | 0.83 | LMNA (0.76) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL6573530 | 0.78 | CYP2C19 (0.74) | SMN1; SMN2LMNAALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL28677732 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL9246238 | 0.78 | LMNA (0.72) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL6573581 | 0.76 | MAPT (0.50) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL27672667 | 0.76 | LMNA (0.66) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 | |
| SCHEMBL2969374 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2LMNAALDH1A1GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | claimed |
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |