SCHEMBL6570848

SCHEMBL6570848

COc1cccc(-c2cccc3[nH]c4cc5[nH]c6ccccc6c5cc4c23)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.55
ALDH1A1 P00352 4/20 0.55
MAPT P10636 3/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
HSD17B10 Q99714 2/20 0.55
HPGD P15428 2/20 0.55
AHR P35869 2/20 0.49
NR1I2 O75469 1/20 0.49
CYP1A2 P05177 1/20 0.49
VDR P11473 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2B6 P20813 1/20 0.49
NR1I3 Q14994 1/20 0.49
CHEK1 O14757 1/20 0.46
WEE1 P30291 1/20 0.46
CHRM4 P08173 1/20 0.46
DRD2 P14416 1/20 0.46
HTR7 P34969 1/20 0.46
ATM Q13315 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12180919 0.84 KDM4E (0.56) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL23039563 0.83 AHR (0.53) KDM4EALDH1A1MAPTHSD17B10HPGD
SCHEMBL147991 0.80 PARP14 (0.57) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL23039533 0.79 AHR (0.60) KDM4EALDH1A1MAPTHSD17B10HPGD
SCHEMBL643897 0.76 AURKA (0.52) MAPTMEN1KMT2AAHRNR1I2
SCHEMBL1615076 0.76 BRD4 (0.55) ALDH1A1AHRNR1I2CYP1A2VDR
SCHEMBL26729883 0.75 IMPDH2 (0.53) KDM4EALDH1A1HSD17B10HPGDAHR
SCHEMBL2183104 0.75 CYP11B1 (0.46) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL18429999 0.74 AHR (0.52) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL18429996 0.74 AHR (0.52) ALDH1A1MAPTHSD17B10AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0908787-B1 Indolocarbazole Photoconductors XEROX CORP (US) 2004-04-14 EP claimed
EP-0908787-A2 Indolocarbazole Photoconductors Xerox Corporation (US) 1999-04-14 EP claimed
EP-0908787-A2 Indolocarbazole Photoconductors Xerox Corporation (US) 1999-04-14 EP disclosed