Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 9/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 9/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 9/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570002 | 0.89 | PDK1 (0.65) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6569996 | 0.89 | PDK1 (0.65) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6571153 | 0.84 | CA1 (0.44) | PDK1PDK2PDK3PDK4CA1 | |
| SCHEMBL6571285 | 0.81 | PDK1 (0.74) | PDK1PDK2PDK3PDK4CA1 | |
| SCHEMBL6571279 | 0.81 | PDK1 (0.74) | PDK1PDK2PDK3PDK4CA1 | |
| SCHEMBL6356247 | 0.80 | ABCC9 (0.70) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6356244 | 0.80 | ABCC9 (0.70) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL4609272 | 0.79 | ABCC9 (0.72) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL4609279 | 0.79 | ABCC9 (0.72) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL19450529 | 0.78 | PDK1 (0.56) | PDK1PDK2PDK3PDK4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |