Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358387 | 0.84 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11KCNJ8MAP2K2 | |
| SCHEMBL6568838 | 0.82 | PDK1 (0.56) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6568832 | 0.82 | PDK1 (0.56) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL3628825 | 0.76 | MAP2K2 (0.44) | ABCC9ABCC8KCNJ11KCNJ8MAP2K2 | |
| SCHEMBL6351380 | 0.75 | ABCC9 (0.49) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6571138 | 0.74 | PDK1 (0.61) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6571148 | 0.74 | PDK1 (0.61) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6568153 | 0.73 | PDK1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6568156 | 0.73 | PDK1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6349963 | 0.73 | ABCC9 (0.36) | ABCC9ABCC8KCNJ11KCNJ8MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |