SCHEMBL6571332

SCHEMBL6571332

COCCNc1ccc(N)cc1-c1ccccc1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.49
CYP2C19 P33261 5/20 0.49
ALDH1A1 P00352 4/20 0.49
CLK4 Q9HAZ1 2/20 0.49
USP2 O75604 1/20 0.49
APEX1 P27695 1/20 0.49
CASP7 P55210 1/20 0.49
HSD17B10 Q99714 5/20 0.46
ALOX15 P16050 3/20 0.46
HIF1A Q16665 1/20 0.46
NCF1 P14598 2/20 0.45
CYP3A4 P08684 3/20 0.44
KDM4E B2RXH2 3/20 0.44
TSHR P16473 3/20 0.44
CYP2D6 P10635 1/20 0.44
MAPK1 P28482 1/20 0.44
PTGER4 P35408 3/20 0.43
PLA2G7 Q13093 1/20 0.41
MALT1 Q9UDY8 1/20 0.40
KCNN4 O15554 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572530 0.87 PTGER4 (0.47) CYP1A2CYP2C19ALDH1A1CLK4USP2
SCHEMBL6572270 0.85 ALDH1A1 (0.50) CYP1A2CYP2C19ALDH1A1CLK4USP2
SCHEMBL6572531 0.85 PTGER4 (0.45) CYP1A2CYP2C19ALDH1A1CLK4USP2
SCHEMBL6572757 0.83 PLA2G7 (0.43) CYP1A2CYP2C19ALDH1A1HSD17B10CYP3A4
SCHEMBL6572960 0.83 PTGER4 (0.51) CYP1A2CYP2C19ALDH1A1ALOX15NCF1
SCHEMBL6574666 0.82 PTGER4 (0.50) CYP1A2CYP2C19ALDH1A1CLK4USP2
Hydrochloric Acid SCHEMBL6572054 0.82 PTGER4 (0.50) CYP1A2CYP2C19ALDH1A1ALOX15NCF1
SCHEMBL6572445 0.81 PTGER4 (0.49) CYP1A2CYP2C19ALDH1A1CLK4USP2
SCHEMBL11311817 0.81 PTGER4 (0.50) CYP1A2CYP2C19ALDH1A1CLK4USP2
SCHEMBL6572814 0.80 PTGER4 (0.48) ALDH1A1NCF1MAPK1PTGER4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed