SCHEMBL6571509

SCHEMBL6571509

COCCNc1ccc(N)cc1-c1cccc(OC)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.46
CYP1A2 P05177 3/20 0.46
CYP2C19 P33261 3/20 0.46
ALDH1A1 P00352 3/20 0.46
CYP2D6 P10635 2/20 0.46
HSD17B10 Q99714 2/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
USP2 O75604 1/20 0.46
CLK4 Q9HAZ1 1/20 0.46
KIT P10721 1/20 0.44
PTGER4 P35408 2/20 0.43
SRC P12931 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
TDO2 P48775 1/20 0.42
ADORA2A P29274 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570689 0.91 PTGER4 (0.48) ALDH1A1ALOX15PTGER4SMN1; SMN2LMNA
SCHEMBL6572487 0.87 ALDH1A1 (0.44) CYP3A4ALDH1A1HSD17B10TSHRKIT
SCHEMBL6572731 0.85 PTGER4 (0.46) CYP3A4ALDH1A1HSD17B10ALOX15KIT
SCHEMBL6572960 0.85 PTGER4 (0.51) CYP3A4CYP1A2CYP2C19ALDH1A1CYP2D6
SCHEMBL6572075 0.85 PTGER4 (0.46) ALDH1A1ALOX15PTGER4SRCADORA1
Hydrochloric Acid SCHEMBL6572054 0.84 PTGER4 (0.50) CYP3A4CYP1A2CYP2C19ALDH1A1CYP2D6
SCHEMBL6572005 0.82 PTGER4 (0.50) CYP3A4CYP1A2CYP2C19ALDH1A1CYP2D6
SCHEMBL6572456 0.82 PTGER4 (0.50) CYP1A2CYP2C19ALDH1A1USP2CLK4
SCHEMBL6572380 0.81 ALDH1A1 (0.51) CYP3A4CYP1A2CYP2C19ALDH1A1CYP2D6
SCHEMBL6572446 0.80 PTGER4 (0.40) ALDH1A1PTGER4MAPTNCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed