SCHEMBL6572380

SCHEMBL6572380

CNc1ccc(N)cc1-c1cccc(OC)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
CYP3A4 P08684 3/20 0.51
TDO2 P48775 1/20 0.48
ADORA2A P29274 1/20 0.47
ADORA1 P30542 1/20 0.47
KIT P10721 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
HSD17B10 Q99714 2/20 0.45
LMNA P02545 2/20 0.45
MAPT P10636 1/20 0.45
MAOB P27338 2/20 0.43
TGFBR2 P37173 1/20 0.42
KDM4E B2RXH2 1/20 0.42
KMT2A Q03164 1/20 0.42
CYP19A1 P11511 1/20 0.42
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
FYN P06241 1/20 0.41
CYP1A1 P04798 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3787927 0.84 MAP4K4 (0.49) ALDH1A1CYP3A4KITLMNAMAPT
SCHEMBL6573911 0.83 TDP1 (0.48) ALDH1A1CYP3A4KITSMN1; SMN2HSD17B10
SCHEMBL6572487 0.81 ALDH1A1 (0.44) ALDH1A1CYP3A4TDO2ADORA2AADORA1
SCHEMBL6571509 0.81 CYP3A4 (0.46) ALDH1A1CYP3A4TDO2ADORA2AADORA1
SCHEMBL6571024 0.81 CYP3A4 (0.58) ALDH1A1CYP3A4TDO2ADORA2AADORA1
Hydrochloric Acid SCHEMBL6570983 0.80 ALDH1A1 (0.56) ALDH1A1CYP3A4TDO2ADORA2AADORA1
SCHEMBL6259929 0.80 CYP3A4 (0.56) ALDH1A1CYP3A4TDO2ADORA2AADORA1
SCHEMBL3785718 0.79 MAOA (0.42) ALDH1A1CYP3A4TDO2SMN1; SMN2HSD17B10
SCHEMBL5098820 0.78 ADORA2A (0.47) ALDH1A1ADORA2AADORA1KDM4E
SCHEMBL6573673 0.78 CA12 (0.46) ALDH1A1CYP3A4ADORA2AADORA1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed