Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571662 | 1.00 | KDM4E (0.52) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL11652810 | 0.80 | MAPT (0.54) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL29951440 | 0.78 | ERN1 (0.64) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL5541894 | 0.76 | MAPT (0.58) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL3155534 | 0.75 | KDM4E (0.62) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL8537074 | 0.74 | PTPN22 (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10337519 | 0.74 | ESR1 (0.41) | KDM4EMAPTERN1HTTNPC1 | |
| SCHEMBL8537080 | 0.74 | PTPN22 (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29955571 | 0.74 | MAPT (0.56) | KDM4EMAPTERN1CYP3A4MEN1 | |
| SCHEMBL13351489 | 0.74 | MAPT (0.62) | KDM4EMAPTCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432694-A1 | STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF 2-YL CHROMAN DERIVATIVES | Wyeth (US) | 2004-06-30 | — | — | EP | disclosed |
| US-6716998-B2 | SUCH AS (2R)-3,4-DIHYDRO-2H-CHROMEN-2-YL-METHYL-4-METHYL-BENZENESULFONATE; METATHESIS RING CLOSING POLYMERIZATION | WYETH | 2004-04-06 | — | — | US | disclosed |
| US-20030100774-A1 | Process for synthesis of 2-yl chroman derivatives | WYETH (US) | 2003-05-29 | — | — | US | disclosed |
| WO-2003031428-A1 | STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF 2-YL CHROMAN DERIVATIVES | WYETH (US) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100774-A1 | Process for synthesis of 2-yl chroman derivatives | CDYL, CDY1; CDY1B, CDYL2 | KDM4E 112/4885MAPT 4517/4885ERN1 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.