SCHEMBL6571699

SCHEMBL6571699

N#Cc1c(CCl)[nH]c(=O)[nH]c1=O

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.39
IDO1 P14902 8/20 0.39
ALDH1A1 P00352 7/20 0.38
HPGD P15428 6/20 0.38
KMT2A Q03164 1/20 0.38
TDO2 P48775 1/20 0.35
ATM Q13315 1/20 0.35
TYMP P19971 2/20 0.35
HIF1A Q16665 1/20 0.35
DPYD Q12882 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6060121 0.70 TYMP (0.52) TYMP
SCHEMBL1690845 0.70 TYMP (0.44) KDM4EALDH1A1HPGDKMT2ATYMP
Hydrochloric Acid SCHEMBL1682948 0.69 TYMP (0.62) KDM4EIDO1ALDH1A1HPGDKMT2A
SCHEMBL6694829 0.68 KDM4E (0.52) KDM4EIDO1ALDH1A1HPGDATM
SCHEMBL10371514 0.68 TYMP (0.46) KDM4EIDO1ALDH1A1HPGDTDO2
SCHEMBL475086 0.68 KDM4E (0.46) KDM4EIDO1ALDH1A1HPGDTDO2
SCHEMBL6570508 0.68 TYMP (0.46) TYMP
SCHEMBL6574092 0.68 TYMP (0.50) TYMP
Hydrochloric Acid SCHEMBL1690596 0.68 UPP1 (0.35) KDM4EIDO1ALDH1A1HPGDKMT2A
SCHEMBL9640574 0.64 GAA (0.47) KDM4EIDO1ALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0884051-B1 CANCEROUS METASTASIS INHIBITORS CONTAINING URACIL DERIVATIVES TAIHO PHARMACEUTICAL CO LTD (JP) 2004-12-15 EP disclosed
EP-0763529-B1 URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME TAIHO PHARMACEUTICAL CO LTD (JP) 2003-07-23 EP disclosed
US-6294535-B1 TREATING CANCER, WHICH COMPRISES ADMINISTERING TO A PATIENT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF A URACIL DERIVATIVE TAIHO PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
US-6255314-B1 Cancerous metastasis inhibitors containing uracil derivatives TAIHO CHARMACEUTICAL CO., LTD. (JP) 2001-07-03 US disclosed
US-6159969-A Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same TAIHO PHARMACEUTICAL CO., LTD. (JP) 2000-12-12 US disclosed
EP-0884051-A1 CANCEROUS METASTASIS INHIBITORS CONTAINING URACIL DERIVATIVES TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1998-12-16 EP disclosed
US-5744475-A 4-N-HET-METHYLURACIL DERIVATIVES; THYMIDINE PHOSPHORYLASE INHIBITORS TAIHO PHARMACEUTICAL CO., LTD. (JP) 1998-04-28 US disclosed
EP-0763529-A1 URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1997-03-19 EP disclosed