Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694829 | 0.72 | KDM4E (0.52) | GAAKDM4EALDH1A1HSD17B10ATM | |
| SCHEMBL10371514 | 0.68 | TYMP (0.46) | GAAKDM4EALDH1A1ATMIDO1 | |
| SCHEMBL475086 | 0.68 | KDM4E (0.46) | GAAKDM4EALDH1A1ATMIDO1 | |
| SCHEMBL7289243 | 0.68 | GAA (0.56) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL23183409 | 0.65 | ALDH1A1 (0.41) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL7291664 | 0.65 | GAA (0.41) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL7291463 | 0.65 | GAA (0.41) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL21489613 | 0.64 | KDM4E (0.59) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL10271853 | 0.64 | GAA (0.70) | GAAKDM4EALDH1A1RXFP1KMT2A | |
| SCHEMBL10466353 | 0.64 | GAA (1.00) | GAAKDM4EALDH1A1RXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244360-B1 | SUBSTITUTED PYRIMIDINES | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0273862-B1 | NON-AQUEOUS LIQUID ECTOPARASITICIDAL POUR-ON FORMULATION | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4783468-A | Insecticidal 5-pyrimidine carbonitriles | CIBA-GEIGY CORPORATION (US) | 1988-11-08 | — | — | US | disclosed |
| EP-0273862-A2 | Non-aqueous liquid ectoparasiticidal pour-on formulation | CIBA-GEIGY AG (CH) | 1988-07-06 | — | — | EP | disclosed |
| EP-0244360-A2 | Substituted pyrimidines | CIBA-GEIGY AG (CH) | 1987-11-04 | — | — | EP | disclosed |