SCHEMBL6572124

SCHEMBL6572124

COc1cc(-c2cc(N)ccc2N(CCO)CCO)ccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.41
GAK O14976 1/20 0.36
FYN P06241 2/20 0.35
RIPK2 O43353 1/20 0.35
TGFBR1 P36897 1/20 0.35
ACVR1 Q04771 1/20 0.35
RORC P51449 2/20 0.35
ALDH1A1 P00352 3/20 0.34
KMO O15229 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CHEK1 O14757 1/20 0.34
SUV39H2 Q9H5I1 1/20 0.34
MAPT P10636 2/20 0.33
TSHR P16473 2/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
PDCD1 Q15116 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572169 0.88 DYRK1A (0.41) DYRK1AFYNRIPK2TGFBR1ACVR1
SCHEMBL6573366 0.84 CYP3A4 (0.42) KMOTSHRCYP3A4
SCHEMBL6571974 0.82 ALDH1A1 (0.42) ALDH1A1MAPTGAAMAPK1CYP3A4
SCHEMBL6571903 0.80 KMT2A (0.38) ALDH1A1MAPTGAAHSD17B10
SCHEMBL6570840 0.80 ALDH1A1 (0.36) ALDH1A1L3MBTL1MAPTTSHRGAA
SCHEMBL6570737 0.79 MEN1 (0.47) ALDH1A1L3MBTL1MAPTGAAHTT
SCHEMBL6573155 0.79 PTGS2 (0.40) FYNPTGS1PTGS2
SCHEMBL6571136 0.78 DYRK1A (0.41) DYRK1AGAKFYNRIPK2TGFBR1
SCHEMBL6572448 0.78 ALDH1A1 (0.44) FYNALDH1A1MAPTCYP3A4HSD17B10
SCHEMBL6570740 0.77 ALDH1A1 (0.38) ALDH1A1L3MBTL1MAPTTSHRHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed