Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 0.72 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927368 | 0.87 | MCHR1 (0.93) | MCHR1HTR2CHTR1DHTR1BHTR2A | |
| Trifluoroacetic Acid SCHEMBL6570567 | 0.87 | MCHR1 (0.72) | MCHR1HTR2C | |
| Trifluoroacetic Acid SCHEMBL6569170 | 0.85 | MCHR1 (0.72) | MCHR1HTR2C | |
| Trifluoroacetic Acid SCHEMBL6570904 | 0.85 | MCHR1 (0.71) | MCHR1HTR2CCYP1A2CYP3A4 | |
| SCHEMBL6569132 | 0.85 | MCHR1 (0.75) | MCHR1HTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL6569200 | 0.84 | MCHR1 (0.80) | MCHR1HTR2C | |
| Trifluoroacetic Acid SCHEMBL6570867 | 0.83 | MCHR1 (0.69) | MCHR1HTR2C | |
| Trifluoroacetic Acid SCHEMBL6930451 | 0.83 | MCHR1 (0.84) | MCHR1HTR2C | |
| SCHEMBL6926340 | 0.83 | MCHR1 (0.92) | MCHR1HTR2C | |
| SCHEMBL6569196 | 0.81 | MCHR1 (0.76) | MCHR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140072-B1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-04-14 | — | — | EP | disclosed |
| EP-1140072-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1140072-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040239-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |