Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6572998

COC(=O)Nc1ccc(NC(=O)Cn2cc[n+](CC(=O)Nc3ccc(NC(=O)OC)cc3O)c2)c(O)c1.[Cl-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
HSP90AA1 P07900 1/20 0.37
ALDH1A1 P00352 5/20 0.36
POLB P06746 2/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36
TUBA1C Q9BQE3 1/20 0.36
TUBB6 Q9BUF5 1/20 0.36
TUBB2B Q9BVA1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572652 0.99 CYP1A2 (0.38) CYP1A2CYP2C9CYP2C19HSP90AA1ALDH1A1
Hydrochloric Acid SCHEMBL7629738 0.96 HSP90AA1 (0.39) CYP1A2CYP2C9CYP2C19HSP90AA1ALDH1A1
Hydrochloric Acid SCHEMBL6573111 0.89 POLB (0.38) CYP2C9CYP2C19HSP90AA1ALDH1A1POLB
SCHEMBL6575606 0.88 POLB (0.39) CYP1A2CYP2C9CYP2C19ALDH1A1POLB
Hydrochloric Acid SCHEMBL7638035 0.87 POLB (0.40) CYP1A2CYP2C9CYP2C19HSP90AA1ALDH1A1
Hydrochloric Acid SCHEMBL6942087 0.87 CYP2C19 (0.38) CYP1A2CYP2C9CYP2C19ALDH1A1TUBB4A
SCHEMBL6939926 0.86 CYP2C19 (0.39) CYP1A2CYP2C9CYP2C19ALDH1A1TUBB4A
Hydrochloric Acid SCHEMBL5526645 0.84 HPGD (0.49) CYP1A2CYP2C19HPGDKMT2AMEN1
Hydrochloric Acid SCHEMBL7632194 0.83 ALDH1A1 (0.42) CYP1A2CYP2C9CYP2C19ALDH1A1POLB
Hydrochloric Acid SCHEMBL7635532 0.83 POLB (0.39) CYP1A2CYP2C9CYP2C19ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066263-B1 NOVEL CATIONIC 2-ACYLAMINOPHENOLS, THEIR USE AS COUPLER FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM, AND DYEING METHODS OREAL (FR) 2004-05-26 EP claimed
US-6455737-B1 CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS L'OREAL S.A. (FR) 2002-09-24 US claimed
US-6455737-B1 CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS L'OREAL S.A. (FR) 2002-09-24 US disclosed