Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572851 | 0.99 | POLB (0.38) | POLBALDH1A1MAPTDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL7156926 | 0.86 | KMT2A (0.42) | ALDH1A1MAPTDRD2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6941558 | 0.86 | POLB (0.39) | POLBALDH1A1MAPTKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6942701 | 0.86 | POLB (0.39) | POLBALDH1A1MAPTKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6573313 | 0.86 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL7798700 | 0.85 | KMT2A (0.43) | ALDH1A1MAPTDRD2KDM4ELMNA | |
| SCHEMBL6941689 | 0.85 | POLB (0.40) | POLBALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL6942033 | 0.85 | POLB (0.40) | POLBALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL6575877 | 0.84 | MEN1 (0.42) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6937225 | 0.84 | POLB (0.38) | POLBALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066264-B1 | NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS | OREAL (FR) | 2004-11-17 | — | — | EP | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |