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SCHEMBL657351

SCHEMBL657351

CC(=O)OCOC(=O)C(C(=O)OCOC(C)=O)C(CC(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 4/20 0.67
▸ ALDH1A1 P00352 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HSD11B1 P28845 1/20 0.41
▸ LDHA P00338 2/20 0.41
▸ LDHB P07195 2/20 0.41
▸ PTPN1 P18031 2/20 0.40
▸ GSK3B P49841 2/20 0.40
▸ CYP1A2 P05177 2/20 0.38
▸ CYP3A4 P08684 2/20 0.38
▸ CYP2C9 P11712 2/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CYP2C19 P33261 2/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ BACE1 P56817 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ EEF2K O00418 1/20 0.37
▸ NR4A1 P22736 1/20 0.37
▸ NR4A2 P43354 1/20 0.37
▸ NR4A3 Q92570 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL658835 0.89 PDPK1 (0.52) PDPK1ALDH1A1MAPTPTPN1GSK3B
SCHEMBL658600 0.84 PDPK1 (0.48) PDPK1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL657803 0.83 PDPK1 (0.47) PDPK1ALDH1A1SMN1; SMN2KMT2A
SCHEMBL658661 0.81 PDPK1 (1.00) PDPK1HSD11B1LDHALDHBPTPN1
SCHEMBL25737214 0.81 PDPK1 (0.79) PDPK1ALDH1A1MAPTHSD11B1LDHA
SCHEMBL657948 0.80 PDPK1 (0.50) PDPK1ALDH1A1MAPTPTPN1SMN1; SMN2
SCHEMBL657352 0.78 PDPK1 (0.47) PDPK1ALDH1A1MAPTHSD11B1LDHA
SCHEMBL656362 0.76 ALDH1A1 (0.48) PDPK1ALDH1A1CYP1A2TSHRCYP2C19
SCHEMBL435671 0.75 PDPK1 (0.64) PDPK1ALDH1A1MAPTHSD11B1LDHA
SCHEMBL658474 0.74 PDPK1 (0.56) PDPK1ALDH1A1MAPTLDHALDHB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120202190-A Isoquinoline derivatives as protein degrading agents, E7 degrading agents, antiviral agents, tumor therapeutic agents and immunosuppressants RDP制药股份公司 2025-06-24 — — CN claimed
EP-4548977-A2 NOVEL ISOQUINOLINES AS PROTEIN DEGRADERS, E7 DEGRADERS, ANTIVIRALS, TUMOR THERAPEUTICS AND IMMUNE SUPPRESSIVES RDP Pharma AG (CH) 2025-05-07 — — EP claimed
EP-4322949-A1 ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS RDP Pharma AG (CH) 2024-02-21 — — EP claimed
CN-117377474-A Isoquinoline derivatives as antiviral and antitumor agents RDP制药股份公司 2024-01-09 — — CN claimed
WO-2022219157-A1 ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS VALDOSPAN GMBH (AT) 2022-10-20 — — WO claimed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 — — US claimed
EP-4736874-A1 METHODS FOR PREDICTING AND IMPROVING THE EFFICACY OF CAR T-CELL THERAPY Fondazione Matilde Tettamanti e Menotti de Marchi Onlus (IT) 2026-05-06 — — EP disclosed
US-20260061069-A1 SIZE-TUNABLE SYNTHETIC PARTICLES FOR IMMUNE CELL ACTIVATION SLINGSHOT BIOSCIENCES INC (US) 2026-03-05 — — US disclosed
US-20250389633-A1 SYNTHETIC HUMAN CELL MIMIC PARTICLE FOR CYTOMETRIC OR COULTER DEVICE SLINGSHOT BIOSCIENCES, INC. (US) 2025-12-25 — — US disclosed
US-20250341526-A1 NOVEL DYES Quantum-Si Incorporated (US) 2025-11-06 — — US disclosed
US-12461007-B2 CD34 stem cell mimics SLINGSHOT BIOSCIENCES, INC. (US) 2025-11-04 — — US disclosed
EP-4616853-A1 LIPO-HYDROXAMIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF Medicibio Co., Ltd (KR) 2025-09-17 — — EP disclosed
EP-4605376-A1 ISOQUINOLINE DERIVATIVES AS PROTEIN DEGRADERS, E7 DEGRADERS, ANTIVIRALS, TUMOR THERAPEUTICS AND IMMUNE SUPPRESSIVES RDP Pharma AG (CH) 2025-08-27 — — EP disclosed
CN-110971205-B High-linearity variable gain amplifier and electronic device 华为技术有限公司 2022-08-09 — — CN disclosed
EP-4006153-A1 ENHANCED IMMUNE CELLS USING DUAL SHRNA AND COMPOSITION INCLUDING THE SAME Curocell Inc. (KR) 2022-06-01 — — EP disclosed
CN-107615062-B Hydrogel particles with tunable optical properties and methods of using the same 弹弓生物科学公司 2022-03-18 — — CN disclosed
US-20220056527-A1 USE OF SHROOM3 IN CHRONIC KIDNEY DISEASE AND CHRONIC ALLOGRAFT NEPHROPATHY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-02-24 — — US disclosed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 — — EP disclosed
US-8912186-B2 Allosteric protein kinase modulators UNIVERSITAET DES SAARLANDES (DE) 2014-12-16 — — US disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260061069-A1 SIZE-TUNABLE SYNTHETIC PARTICLES FOR IMMUNE CELL ACTIVATION ICOS, CD47, CD4 PDPK1 2983/4885ALDH1A1 4461/4885MAPT 2952/4885
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB PDPK1 109/4885ALDH1A1 4784/4885MAPT 964/4885
US-20250389633-A1 SYNTHETIC HUMAN CELL MIMIC PARTICLE FOR CYTOMETRIC OR COULTER DEVICE CD4, ICOS, CD69 PDPK1 3880/4885ALDH1A1 3752/4885MAPT 1949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.