SCHEMBL6573635

SCHEMBL6573635

CCCCCCCCCCCCNC(=O)[C@@H](N)Cc1c[nH]c2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 3/20 0.60
MMP8 P22894 3/20 0.60
MMP1 P03956 2/20 0.60
TERT O14746 2/20 0.59
ACHE P22303 9/20 0.59
BCHE P06276 8/20 0.59
MMP7 P09237 1/20 0.58
KDM4E B2RXH2 1/20 0.58
MEN1 O00255 1/20 0.58
LMNA P02545 1/20 0.58
MPO P05164 1/20 0.58
MAPT P10636 1/20 0.58
TSHR P16473 1/20 0.58
BLM P54132 1/20 0.58
PMP22 Q01453 1/20 0.58
KMT2A Q03164 1/20 0.58
HIF1A Q16665 1/20 0.58
MTNR1A P48039 1/20 0.57
MMP9 P14780 1/20 0.57
HDAC8 Q9BY41 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17941647 1.00 MMP2 (0.60) MMP2MMP8MMP1TERTACHE
SCHEMBL20281025 1.00 MMP2 (0.60) MMP2MMP8MMP1TERTACHE
SCHEMBL10548878 1.00 MMP2 (0.60) MMP2MMP8MMP1TERTACHE
SCHEMBL20657707 1.00 MMP2 (0.60) MMP2MMP8MMP1TERTACHE
SCHEMBL20657708 1.00 MMP2 (0.60) MMP2MMP8MMP1TERTACHE
SCHEMBL25080947 0.95 KDM4E (0.61) TERTACHEBCHEKDM4EMEN1
SCHEMBL27163831 0.95 KDM4E (0.61) TERTACHEBCHEKDM4EMEN1
SCHEMBL30812923 0.95 KDM4E (0.61) TERTACHEBCHEKDM4EMEN1
Hydrochloric Acid SCHEMBL21082975 0.93 ACHE (0.65) TERTACHEBCHEKDM4EMEN1
Hydrochloric Acid SCHEMBL21082961 0.93 ACHE (0.65) TERTACHEBCHEKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0558648-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 2004-04-28 EP disclosed
EP-0663823-B1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 2000-11-22 EP disclosed
US-5892112-A ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS GLYCOMED INCORPORATED (US) 1999-04-06 US disclosed
US-5773438-A SKIN DISORDERS, RESTENOSIS, RHEUMATIC ARTHRITIS, WOUND HEALING AGENTS, ANGIOGENESIS, SHOCK GLYCOMED INCORPORATED (US) 1998-06-30 US disclosed
EP-0558681-B1 TREATMENT FOR TISSUE ULCERATION UNIV FLORIDA (US) 1998-04-08 EP disclosed
US-5696147-A CONTROLLING GROWTH OF TUMORS AND NEOVASCULAR GLAUCOMAS GLYCOMED, INC. (US) 1997-12-09 US disclosed
EP-0558635-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 1997-09-10 EP disclosed
EP-0663823-A4 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS. GLYCOMED INC (US) 1997-06-04 EP disclosed
EP-0692931-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-20 EP disclosed
EP-0690841-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-13 EP disclosed
EP-0558648-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY, Richard, E. (US) 1993-09-08 EP disclosed
US-5239078-A Collagenase enzyme inhibitors GLYCOMED INCORPORATED (US) 1993-08-24 US disclosed
WO-1993013741-A2 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1993-07-22 WO disclosed
US-5189178-A Preventing protein destruction GALARDY RICHARD E (US) 1993-02-23 US disclosed
US-5183900-A Matrix metalloprotease inhibitors GALARDY RICHARD E (US) 1993-02-02 US disclosed
WO-1992009563-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1992-06-11 WO disclosed
WO-1992009556-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 1992-06-11 WO disclosed
WO-1992009282-A1 TREATMENT FOR TISSUE ULCERATION THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 1992-06-11 WO disclosed
US-5114953-A Peptides UNIVERSITY OF FLORIDA (US) 1992-05-19 US disclosed
US-4831038-A ANTITUMOR ALKALOIDS IRE-CELLTARG S.A. (BE) 1989-05-16 US disclosed