SCHEMBL6573758

SCHEMBL6573758

CCOP(Oc1ccccc1)O[Si](C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.36
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CA4 P22748 1/20 0.31
MAPT P10636 1/20 0.30
CHRNB2 P17787 1/20 0.30
CHRNB4 P30926 1/20 0.30
CHRNA3 P32297 1/20 0.30
CHRNA7 P36544 1/20 0.30
CHRNA4 P43681 1/20 0.30
RELA Q04206 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL385592 0.85 LTA4H (0.43) LTA4HTP53CA4CHRNB2CHRNB4
SCHEMBL443626 0.85 LTA4H (0.43) LTA4HTP53CA4CHRNB2CHRNB4
SCHEMBL16587354 0.85 CA4 (0.39) LTA4HCA4
SCHEMBL11557684 0.83 LTA4H (0.42) LTA4HTP53CA4CHRNB2CHRNB4
SCHEMBL11675392 0.81 LTA4H (0.41) LTA4HTP53CA4CHRNB2CHRNB4
SCHEMBL10497426 0.79 LTA4H (0.39) LTA4HCA4CHRNB2CHRNB4CHRNA3
SCHEMBL20710847 0.76 RAB9A (0.41) LTA4HKDM4ENPC1ALDH1A1TP53
SCHEMBL20710810 0.76 LTA4H (0.41) LTA4HNPC1HPGDRAB9ASMN1; SMN2
SCHEMBL20710748 0.76 CA4 (0.52) LTA4HNPC1ALDH1A1RAB9ACA4
Carbon Monoxide SCHEMBL11756856 0.76 LTA4H (0.37) LTA4HNPC1HPGDRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0642507-B1 TRANSITION STATE ANALOGUES OF COCAINE, THEIR USE FOR PRODUCING CATALYTIC ANTIBODIES AGAINST COCAINE AND USE OF THE SAME IN DIAGNOSIS AND THERAPY UNIV COLUMBIA (US) 2004-02-04 EP disclosed
US-6566084-B1 Detecting hydrolysis of cocaine compound; obtain cocaine mixture, incubate with antibody, monitor generation of benzoic zacid THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2003-05-20 US disclosed
US-6184013-B1 ANTIBODY FOR REDUCING CONCENTRATION OF DRUG IN PATIENT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2001-02-06 US disclosed
US-5990285-A ANTIBODY CAPABLE OF BINDING A TRANSITION STATE ANALOG FOR THE HYDROLYSIS OF COCAINE BENZOYL ESTER GROUP; TREATMENT OF DRUG ABUSE, DRUG DEPENDENCE, OVERDOSES THE TRUSTEES OF COLUMBIA UNIVERSITY (US) 1999-11-23 US disclosed
US-5977314-A ANTIBODY CAPABLE OF CATALYZING THE HYDROLYSIS OF COCAINE AT BENZOYL ESTER GROUP AND AGAINST SPECIFIC STRUCTURAL COMPOUNDS LISTED; FOR DECREASING CONCENTRATION OF COCAINE IN A SUBJECT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1999-11-02 US disclosed
EP-0642507-A4 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME. 1995-03-29 EP disclosed
EP-0642507-A1 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME The Trustees of Columbia University in the City of New York (US) 1995-03-15 EP disclosed
WO-1993020076-A1 CATALYTIC ANTIBODIES AGAINST COCAINE AND METHODS OF USING AND PRODUCING SAME THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1993-10-14 WO disclosed