Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5687671 | 0.87 | LOXL2 (0.52) | BACE1LOXL2HRH3KLKB1ABAT | |
| SCHEMBL6572315 | 0.84 | BACE1 (0.49) | BACE1LOXL2KLKB1PDE10AALDH1A1 | |
| SCHEMBL3789852 | 0.84 | PDE10A (0.54) | BACE1PDE10AMAPTKDM4ETDP1 | |
| SCHEMBL6575899 | 0.84 | BACE1 (0.53) | BACE1PDE10AMAPTKDM4ETDP1 | |
| SCHEMBL6572376 | 0.84 | BACE1 (0.53) | BACE1PDE10AMAPTKDM4ETDP1 | |
| SCHEMBL28060034 | 0.83 | ABAT (0.56) | BACE1HRH3ABATMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL6780409 | 0.83 | BACE1 (0.47) | BACE1LOXL2KLKB1PDE10AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6778117 | 0.82 | BACE1 (0.51) | BACE1PDE10AMAPTKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL6786651 | 0.82 | BACE1 (0.51) | BACE1PDE10AMAPTKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL6787402 | 0.82 | PDE10A (0.52) | BACE1PDE10AMAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208077-B1 | 2-HYDROXY-5-AMINO-BIPHENYL-DERIVATIVES AND OXIDATIVE HAIR COLOURING AGENTS CONTAINING SAID COMPOUNDS | WELLA AG (DE) | 2004-04-21 | — | — | EP | claimed |
| CN-100366233-C | Hair conditioning compositions and application in hair dye composition thereof | PROCTER & GAMBLE (US) | 2008-02-06 | — | — | CN | disclosed |
| CN-1209094-C | Hair coloring compositions and methods | PROCTER & GAMBLE (US) | 2005-07-06 | — | — | CN | disclosed |
| US-6749644-B2 | DEVELOPER AND COUPLER; WIDE RANGE OF DIFFERENT COLOR SHADES FROM BLOND TO BROWN, PURPLE, VIOLET AND EVEN BLUE AND BLACK; INTENSITY | WELLA AKTIENGESELLSCHAFT (DE) | 2004-06-15 | — | — | US | disclosed |
| EP-1208077-B1 | 2-HYDROXY-5-AMINO-BIPHENYL-DERIVATIVES AND OXIDATIVE HAIR COLOURING AGENTS CONTAINING SAID COMPOUNDS | WELLA AG (DE) | 2004-04-21 | — | — | EP | disclosed |
| CN-1479606-A | Hair conditioning composition and use thereof in hair dyeing compositions | 宝洁公司 | 2004-03-03 | — | — | CN | disclosed |
| CN-1427711-A | Hair colouring and conditioning composition | PROCTER & GAMBLE (US) | 2003-07-02 | — | — | CN | disclosed |
| CN-1427710-A | Composition for colouring and conditioning hair | PROCTER & GAMBLE (US) | 2003-07-02 | — | — | CN | disclosed |
| CN-1411361-A | Hair coloring compositions and methods | PROCTER & GAMBLE (US) | 2003-04-16 | — | — | CN | disclosed |
| US-20020166180-A1 | 2-hydroxy-5-amino-biphenyl-derivatives and oxidative hair colouring agents containing said compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2002-11-14 | — | — | US | disclosed |
| CN-1283968-A | Product applicator | PROCTER & GAMBLE (US) | 2001-02-14 | — | — | CN | disclosed |
| CN-1246047-A | Hair coloring compositions | PROCTER & GAMBLE (US) | 2000-03-01 | — | — | CN | disclosed |
| CN-1246046-A | Hair coloring compositions | PROCTER & GAMBLE (US) | 2000-03-01 | — | — | CN | disclosed |
| CN-1246048-A | Hair coloring compositions | PROCTER & GAMBLE (US) | 2000-03-01 | — | — | CN | disclosed |
| CN-1246049-A | Hair coloring compositions | PROCTER & GAMBLE (US) | 2000-03-01 | — | — | CN | disclosed |
| CN-1245413-A | Hair coloring compositions | PROCTER & GAMBLE (US) | 2000-02-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020166180-A1 | 2-hydroxy-5-amino-biphenyl-derivatives and oxidative hair colouring agents containing said compounds | AHR, KRT18, HMOX2 | BACE1 2023/4885LOXL2 557/4885HRH3 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.